

Shining Force II was the first RPG I ever played, back in the days when you could rent the entire console. I absolutely fell in love with that game.
In addition to many listed elsewhere…
Beyond Oasis. Castlevania: Bloodlines. Rocket Knight Adventures. Shadowrun. Phantasy Star series. Castle of Illusion and World of Illusion. Might and Magic II.
And the Genesis version of Earthworm Jim remains the definitive version for me.
Yeah. You can use Dosbox for most things, and Wine will handle some things, but if you want to play Windows titles and emulate specific configurations and 3D cards, etc., you should look into one of these.