Recently there was a thing where VAC would erroneously flag AMD’s antilag+ feature as cheating, and issue a ban.
AMD then quickly disabled the feature by default but now Valve also patched detection for it and is now, at least according to these patch notes, reversing the bans.
My friend can’t play Hell Let Loose because of a game ban on a completely different game. Different anticheat, and different publisher. So. I would be shocked if a VAC ban wouldn’t cause the same issues.