I can vouch for this as someone who’s tried equivalent doses of each, less methamphetamine is required to achieve the same effects but I couldn’t tell the difference. Compared with the recreational forms you’re also dealing with different salts combined in the prescription. This sentiment is also common.
Serotonergic which is minor in high amphetamine doses, they’re more dopaminergic. Serotonin is more SSRIs and psychedelics.