Second on Fedora. It ships pretty bleeding edge software, is very well integrated, has timely updates (new release every 9 months). I’ve set up family and coworkers with it and its kept them going for years with next to no problems. If you install it yourself, you probably want to add the RPM Fusion repository for proprietary video drivers and media codecs.

I use Gentoo personally, but I wouldn’t recommend it unless you have an insatiable compulsion to tinker with things.